Hemodynamic Implications of Sildenafil in Candidates for Heart Transplantation with Group 2 Pulmonary Hypertension: A Single Latin-American Center Registry

PurposeHeart failure is the most common cause of Group 2 pulmonary hypertension (PH). When it becomes fixed, increases morbidity and mortality in heart transplantation (HTx). Reversing this situation difficult, but use selective vasodilators such as sildenafil could be a simple pharmacological tool setting.ObjectivesTo analyze prevalence PH effect Sildenafil HTx candidates its impact on mortality.MethodsPatients who had undergone over ten-year period were analyzed retrospectively. was defined mean artery pressure (PAP) ≥25mmHg and/or vascular resistance (PVR) > 3UW. Among P with those received (Group A) did not B) compared. Quantitative variables compared t-test or Mann-Whitney, nominals Fisher's test. Survival using log-rank A p<0.05 considered significantResultsFrom 01/2008 to 12/2018, 294 HTx, 30 (10%) combined transplantation, pediatric, re-transplantation, without data, excluded. Of 217 analyzed, 153 (70%) presented PH, whom 77P (51%) sildenafil. Baseline characteristics are described Table 1a. The causes for which 76 (49%) receive treatment were: intolerance vasodilators, vasopressors, congestion, tendency reserve patients under previous ACEIs, ARAII ARNI. 1b describes hemodynamic both groups. 1a shows decrease MPAP, transpulmonary gradient, PVR changes cardiac index A. There no difference between groups (graphic 1)ConclusionThe an effective strategy improve profile during candidacy survival. Heart setting. To mortality. Patients significant From 1)